Poynton was born in 1970 in Durban, and lives in Cape Town. A survey of 25 years of her painting, titled Model for a World, showed at The New Church Museum, Cape Town, in mid-2014. She has held eight solo exhibitions at Stevenson, most recently Picnic in Cape Town (2016) and, prior to this, Scenes of a Romantic Nature in Johannesburg (2015). She showed at the KZNSA Gallery, Durban, in 2010, and held her first US solo exhibitions at the Savannah College of Art and Design's galleries in Savannah and Atlanta in 2009.
Group exhibitions include Der Feine Riss: Zeitgenössische Malerei auf dem Historischen Feld (The Subtle Rift: Contemporary Painting in the Historical Frame) at Haus am Lützowplatz, Berlin (2016); Home Truths: Domestic Interiors from South African Collections at the Iziko South African National Gallery (2016); I Love You Sugar Kane, Institute of Contemporary Art Indian Ocean, Port Louis, Mauritius (2016); Eros and Thanatos, SOR Rusche Collection, Oelde/Berlin (2012); Von Liebeslust und Lebenslast - der inszenierte Alltagat, Corvey Castle, near Höxter, Germany (2009); and What lies beneath, Galerie Mikael Andersen, Copenhagen (2006).
Two monographs have been published on her paintings: Everything Matters (SCAD/Stevenson, 2009) and Pictures (Stevenson, 2013).