Mokgosi was born in 1981 in Botswana, and moved to London in 2003 to pursue his tertiary education at the Slade School of Fine Art. He studied for a BA at Williams College, Massachusetts, and attended the Whitney Independent Study Program in New York; thereafter, he completed his MFA under the mentorship of Mary Kelly at UCLA. He is currently an assistant professor at the Gallatin School, New York University.
In 2012 Mokgosi was awarded a Studio Museum residency, and was the recipient of the Mohn Award during the Made in LA biennale at the Hammer Museum in Los Angeles. The latter award included funds for a monograph, titled Pax Kaffraria, which was published in 2014.
Solo shows have taken place at the Fowler Museum, UCLA (2018); Williams College Museum of Art, Massachusetts (2017); Rochester Contemporary Art Center, New York (2017); the Institute of Contemporary Art, Boston (2015), as well as Stevenson, Cape Town (2016); Jack Shainman Gallery, New York (2015, 2016); and Honor Fraser, Los Angeles (2014). Notable group exhibitions include Art/Afrique, le nouvel atelier at Fondation Louis Vuitton (2017); The Ease of Fiction, a travelling exhibition which has shown at CAM Raleigh, North Carolina (2016); the African American Museum, Los Angeles (2016) and the Museum of the African Diaspora (2017); A story within a story…, the eighth Göteborg Biennale (2015); Meanwhile… Suddenly, and Then, the 12th Lyon Biennale (2013); Migrating Identities at the Yerba Buena Center for the Arts, San Francisco (2013); and Primary Sources and The Bearden Project at the Studio Museum, Harlem (both 2012).