Mokgosi was born in 1981 in Botswana, and moved to London in 2003 to pursue his tertiary education at the Slade School of Fine Art. He studied for a BA at Williams College, Massachusetts, and attended the Whitney Independent Study Program in New York; thereafter, he completed his MFA under the mentorship of Mary Kelly at UCLA. He was the an assistant professor at the Gallatin School, New York University and has recently been appointed Associate Professor in Painting/Printmaking at the Yale School of Art.
In 2012 Mokgosi was awarded a Studio Museum residency, and was the recipient of the Mohn Award during the Made in LA biennale at the Hammer Museum in Los Angeles. The latter award included funds for a monograph, titled Pax Kaffraria, which was published in 2014.
Solo shows have taken place at the Baltimore Museum of Art, USA (2018); Fowler Museum, UCLA (2018); Williams College Museum of Art, Massachusetts (2017); Rochester Contemporary Art Center, New York (2017); the Institute of Contemporary Art, Boston (2015), as well as Stevenson, Cape Town (2016); Jack Shainman Gallery, New York (2015, 2016); and Honor Fraser, Los Angeles (2014;2018). Notable group exhibitions include Art/Afrique, le nouvel atelier at Fondation Louis Vuitton (2017); The Ease of Fiction, a travelling exhibition which has shown at CAM Raleigh, North Carolina (2016); the African American Museum, Los Angeles (2016) and the Museum of the African Diaspora (2017); A story within a story…, the eighth Göteborg Biennale (2015); Meanwhile… Suddenly, and Then, the 12th Lyon Biennale (2013); Migrating Identities at the Yerba Buena Center for the Arts, San Francisco (2013); and Primary Sources and The Bearden Project at the Studio Museum, Harlem (both 2012).