Ndzube was born in 1990 in Hofmeyr, Eastern Cape, and lives in Los Angeles. He has a BA Fine Art from the Michaelis School of Fine Art, University of Cape Town.
Solo exhibitions have taken place at Museo Kaluz (2019); CC Foundation, Shanghai (2018); Nicodim Gallery, Los Angeles (2017); and WHATIFTHEWORLD, Cape Town (2016) alongside Stevenson (2019). Group shows include People at Jeffrey Deitch, Los Angeles (2019); New Acquisitions, Rubell Family Collection, Miami (2019); Hacer Noche (Crossing Night) in Oaxaca, Mexico (2018); The Eye Sees Not Itself, Nicodim Gallery, Los Angeles (2017); Hierophant, Nicodim Gallery, Bucharest (2017); Women's Work, Iziko South African National Gallery, Cape Town (2016); Our Lady, Iziko South African National Gallery (2016); The Art of Disruptions, Iziko South African National Gallery (2016); #theopening, Greatmore Studios, Cape Town (2016); Kasi-2-kasi Public Arts Festival as part of Remaking Place, Gordon Institute for Performing & Creative Arts, Cape Town (2015); Revisiting the Latent Archive in Sites, The Hostel, Cape Town (2015) and Peter Clarke and Friends, Frank Joubert Art Centre.
Ndzube has completed residencies at Dalton Warehouse Studios, South Central, Los Angeles (2018) and Greatmore Studios, Woodstock Cape Town (2016). He is the recipient of the Culture Creators 'Innovators & Leaders' Award in Art (2019) the Tollman Award for Visual Art (2016); and the Michaelis Prize (2015); Simon Gerson Prize (2015) and Cecil Skotnes Scholarship (2013) at UCT.
Simphiwe Ndzube will feature in the 15th Edition of the Lyon Biennale titled Là où les eaux se mêlent (where water comes together with other water).